AP2-α is required for normal thymus development

Thymus Development BMP Signaling Is Required for Normal

Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus

The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc in development we generated a floxed allele. These mice were mated with a strain carrying Cre re...

Α-actinin-4 Is Required for Normal Podocyte Adhesion

Savita V. Dandapani, Hikaru Sugimoto, Benjamin D. Matthews, Robert J. Kolb, Sumita Sinha Robert E. Gerszten, Jing Zhou, Donald E. Ingber, Raghu Kalluri, Martin R. Pollak Department of Genetics, Harvard Medical School, Boston, MA, Renal Division, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA Division of Matrix Biology, Beth Israel Deaconess Medical C...

Pbx3 is required for normal locomotion and dorsal horn development.

The transcription cofactor Pbx3 is critical for the function of hindbrain circuits controlling respiration in mammals, but the perinatal lethality caused by constitutively null mutations has hampered investigation of other roles it may play in neural development and function. Here we report that the conditional loss of Pbx3 function in most tissues caudal to the hindbrain resulted in progressiv...

Erythropoietin receptor signalling is required for normal brain development.

Erythropoietin, known for its role in erythroid differentiation, has been shown to be neuroprotective during brain ischaemia in adult animal models. Although high levels of erythropoietin receptor are produced in embryonic brain, the role of erythropoietin during brain development is uncertain. We now provide evidence that erythropoietin acts to stimulate neural progenitor cells and to prevent ...